Thursday, September 26, 2013

Quintiles Advances New Approach to Speed Biomarker-Targeted Therapies to Cancer Patients

Undertakes Novel Genomic “Pre-profiling” Feasibility Study to Examine the Promise of Precision Medicine in Metastatic Colorectal Cancer Patients

ME Newswire / Business Wire

RESEARCH TRIANGLE PARK, N.C. - Wednesday, September 25th 2013

Quintiles today announced plans to improve the development of biomarker-targeted therapies through a novel approach that promotes the genomic “pre-profiling” of cancer patients. As a first step, Quintiles is undertaking a study with the participation of US Oncology Research, supported by McKesson Specialty Health and The US Oncology Network, to explore the operational feasibility and clinical benefits of an upfront approach to the genomic profiling of tumors from metastatic colorectal cancer (mCRC) patients. The study will investigate how pre-profiling and genomic sequencing data may support physician treatment decisions, including the identification of appropriate clinical trials for patients.

“Today, the industry’s approach to stratifying patients through genomic screening is sequential – testing for oncology biomarkers one at a time, and often only as part of screening for participation in a single clinical trial,” explained Jeffrey Spaeder, M.D., chief medical and scientific officer for Quintiles. “Early indications from this study suggest that we can provide physicians and patients with early visibility on potentially clinically actionable biomarkers within a rapid two-week timeframe. This level and speed of analysis has promise to save valuable time in administering potentially life-saving therapies to patients, and reduce the development times of precision medicines.”

As cancer research and care enter the era of precision medicine, Quintiles is actively transforming the model for testing new therapies. Pre-profiling may accelerate early testing of new biomarker-targeted therapies by enabling biopharmaceutical companies to focus on molecules with high potential for safety and effectiveness. For cancer patients and physicians, pre-profiling enables the efficient matching of the right patients to the right clinical studies, and increases patient access to innovative therapies.

“Our work is taking a critical step toward making precision medicine a reality,” continued Spaeder. “Quintiles’ end-to-end design and delivery model for connecting genomic testing with clinical trials supports the needs of patients, physicians and drug developers. Our goal is to provide oncology investigators and their patients with access to effective, cutting-edge therapies through a model built upon experience and high-quality cancer care.”

About the “Pre-profiling” Feasibility Study

The primary objective of the study, titled “Feasibility study of Biomarker Analysis for Patients with Metastatic Colorectal Cancer,” is to determine the number of genetic changes that occur within mCRC patients that are targeted by U.S. Food and Drug Administration approved therapies, as well as those targeted by therapies in development. The study will perform a broad-based biomarker analysis on mCRC patients, and the results will be reported to the treating physicians in a clinically meaningful format to help identify higher-risk patients and aid in selecting better treatment options.

About Quintiles

Quintiles (NYSE: Q) is the world’s largest provider of biopharmaceutical development and commercial outsourcing services with a network of more than 27,000 employees conducting business in approximately 100 countries. We have helped develop or commercialize all of the top-50 best-selling drugs on the market. Quintiles applies the breadth and depth of our service offerings along with extensive therapeutic, scientific and analytics expertise to help our customers navigate an increasingly complex healthcare environment as they seek to improve efficiency and effectiveness in the delivery of better healthcare outcomes. To learn more about Quintiles, please visit www.quintiles.com.

Forward-Looking Statements

This press release may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such forward-looking statements reflect, among other things, Quintiles’ current expectations and anticipated results of operations, all of which are subject to known and unknown risks, uncertainties and other factors that may cause Quintiles’ actual results, performance or achievements, market trends, or industry results to differ materially from those expressed or implied by such forward-looking statements. Therefore, any statements contained herein that are not statements of historical fact may be forward-looking statements and should be evaluated as such. Without limiting the foregoing, the words “anticipates,” “believes,” “estimates,” “expects,” “intends,” “may,” “plans,” “projects,” “should,” “targets,” “will” and the negative thereof and similar words and expressions are intended to identify forward-looking statements. These statements are subject to risks, uncertainties and assumptions described under the section entitled "Risk Factors" in Quintiles’ prospectus dated May 8, 2013, filed with the Securities and Exchange Commission (“SEC”) on May 9, 2013, as such factors may be updated from time to time in Quintiles’ periodic filings with the SEC, which are accessible on the SEC's website at www.sec.gov. These factors should not be construed as exhaustive and should be read in conjunction with the other cautionary statements that are included in this release and in Quintiles’ filings with the SEC. Unless legally required, Quintiles assumes no obligation to update any such forward-looking information to reflect actual results or changes in the factors affecting such forward-looking information.

Click here to subscribe to Mobile Alerts for Quintiles.

Contacts

Quintiles

Mari Mansfield, + 1-919-998-2639

Media Relations

mari.mansfield@quintiles.com

Mobile: +1-919-259-3298



Karl Deonanan, +1-919-998-2789

Investor Relations

InvestorRelations@quintiles.com







Permalink: http://www.me-newswire.net/news/8609/en

Thuraya Appoints Vice President of Innovation

Dubai, United Arab Emirates - Tuesday, September 24th 2013 [ME NewsWire]

Thuraya Telecommunications Company, a leading Mobile Satellite Services operator today announced that Randy C. Roberts has joined the Company as Vice President of Innovation. In the newly created role, Roberts will oversee product development, product management and solutions engineering. Roberts will report to Samer Halawi, Chief Executive Officer of Thuraya and will serve as a member of the Company’s Executive Team.

“I am pleased to welcome Randy Roberts as Vice President of Innovation,” said Halawi. “His extensive experience in product development and management with leading handset OEMs will be a strong asset for Thuraya as we drive new product innovation and expand our offerings, including the Thuraya SatSleeve to new audiences and new sectors.”

Roberts is a seasoned telecommunications executive with over 25 years of experience at leading mobile device manufacturers. He brings to Thuraya a wealth of experience in application, hardware and software development, in addition to a strong background in product development and management.

Roberts joins Thuraya from Siemens Enterprise Communications where he was the Vice President of their Global Mobile Product Portfolio. Roberts has held a variety of leadership roles in product management and development at BlackBerry, Motorola, Nokia and AT&T. Roberts holds a Bachelor of Business Administration in Finance from Texas Tech University.

-Ends-

About Thuraya Telecommunications Company

Thuraya Telecommunications Company is an industry leading MSS operator and a global telecommunication provider offering innovative communications solutions to a variety of sectors including energy, broadcast media, maritime, military and humanitarian NGO. Thuraya’s superior network enables clear communications and uninterrupted coverage across two thirds of the globe by satellite and across the whole planet through its unique GSM roaming capabilities. The company’s diverse range of technologically superior and highly reliable mobile satellite handsets and broadband devices provide ease of use, value, quality and efficiency. Thuraya remains committed to serving humanity through delivering the essential tools for optimal connectivity, never leaving anyone out of reach. Visit www.thuraya.com

Contacts

Thuraya

Shereen Hanafi, Director of Communications

+ 971-4-4488-888

corporatecomms@thuraya.com

Follow Thuraya on: Facebook, LinkedIn, Twitter and YouTube

Wednesday, September 25, 2013

Data presented at EASD support safety profile of Trajenta® (linagliptin) in broad range of adults with Type 2 Diabetes

INGELHEIM, Germany and INDIANAPOLIS, US - Tuesday, September 24th 2013 [ME NewsWire]

    Pooled analysis of trial data showed linagliptin was well tolerated including in the elderly with normal renal function to severe renal impairment
    The overall incidence of adverse events was similar for linagliptin compared to placebo

(BUSINESS WIRE)-- For Non-US and Non-UK Media

Poster No. 926 & 986

Boehringer Ingelheim and Eli Lilly and Company today announced that results from two different pooled analyses of clinical studies support previous observations that the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin was shown to be well tolerated in a broad range of adults with Type 2 Diabetes (T2D). These data were presented at the 49th European Association of Diabetes (EASD) Annual Meeting.

General safety analysis

Findings from a pooled comprehensive analysis of safety data in 22 linagliptin clinical trials with 7,400 people with T2D (4,810 received linagliptin, 2,590 received placebo) included the following:1

    Linagliptin was well tolerated overall and across all age groups studied, with a low incidence of hypoglycemic events
    In an exploratory analysis, overall hypoglycaemia was lower for linagliptin compared to placebo (11.5 percent versus 14 percent, p=0.0021)
    Overall incidence of adverse events (AE) or serious adverse events (SAE) with linagliptin was similar to placebo (AE 56.5 percent versus 61.2 percent, and SAE 4.8 percent versus 6.3 percent, respectively)
    The incidence of AEs with linagliptin compared to placebo remained similar irrespective of the age category (≤65 years, 65-74 years, ≥75 years)

“Drug tolerability is an important consideration in the selection of appropriate treatments for people with Type 2 Diabetes, as often different populations will have drug contra-indications and require dose adjustments to manage their disease,” said Prof. Nikolaus Marx, Professor of Medicine and Cardiology, University Hospital of Aachen, Germany. “The results presented today support the safety profile of linagliptin.”

Renal safety in the elderly

Results from a post-hoc analysis of pooled data from seven clinical trials including 1,293 people with T2D aged 65 years or older showed:2

    Linagliptin was well tolerated providing clinical efficacy in an elderly population with renal function ranging from normal to severe renal impairment
    Overall renal function was not significantly altered by treatment with linagliptin from baseline to week 24, versus placebo
    Patients taking linagliptin achieved a HbA1c reduction of -0.6 percent from baseline and −0.8 mmol/L for fasting plasma glucose (both values placebo-corrected)
    The overall incidence of AEs with linagliptin was similar to placebo (71.3 percent versus 72.8 percent, respectively)
    Incidence of investigator-defined hypoglycaemia was not higher in patients who received linagliptin compared to those receiving placebo (21.3 percent versus 24.7 percent), with most events occurring in the trials that included a sulphonylurea or basal insulin as background therapy
    Renal and urinary AEs were experienced by 5.5 percent and 4.3 percent of linagliptin and placebo patients, respectively

“The data presented from these analyses supplement the already established evidence demonstrating that linagliptin is a well-tolerated treatment for a broad range of people with Type 2 Diabetes,” said Professor Klaus Dugi, Corporate Senior Vice President Medicine, Boehringer Ingelheim. “This should provide physicians further assurance when treating different patient types with linagliptin.”

The U.S. Food and Drug Administration (FDA), European Medicines Agency (EMA) and several other regulatory authorities worldwide have approved linagliptin for the treatment of adults with T2D as monotherapy or in combination with metformin, metformin + sulphonylurea, and as add-on therapy to insulin. With linagliptin, no dose adjustment is required regardless of renal function or hepatic impairment.3,4

About Linagliptin

Linagliptin (5 mg) is marketed in Europe as Trajenta® (linagliptin) and in the U.S. as Tradjenta® (linagliptin), as a once-daily tablet that is used along with diet and exercise to improve glycaemic control in adults with T2D. Linagliptin should not be used in patients with Type 1 Diabetes or for the treatment of diabetic ketoacidosis (increased ketones in the blood or urine).3,4

Please click on the link below for ‘Notes to Editors’ and ‘References’

http://www.boehringer-ingelheim.com/news/news_releases/press_releases/2013/24_september_2013linagliptin.html

Contacts

Boehringer Ingelheim GmbH

Dr. Petra Kienle

Launch and Established Products CVM

Email: press@boehringer-ingelheim.com

Phone: +49 (6132) 77-143877



Lilly Diabetes

Tammy Hull

Communications Manager

Email: hullta@lilly.com

Phone: +1 (317) 651 9116







Permalink: http://www.me-newswire.net/news/8602/en

Pooled analysis data showed improvements in glycaemic parameters, body weight and blood pressure with investigational agent empagliflozin* in adults with Type 2 Diabetes

Pooled data from four Phase III trials presented at the 49th EASD Annual Meeting

ME Newswire / Business Wire

INGELHEIM, Germany & INDIANAPOLIS, US - Tuesday, September 24th 2013

For Non-US and Non-UK Media

Poster No. 943 and 944

Boehringer Ingelheim and Eli Lilly and Company today announced results from a new analysis of pooled efficacy data from four Phase III trials that showed treatment with investigational compound empagliflozin*, a member of the sodium glucose cotransporter 2 (SGLT2) inhibitor class of drugs, improved glycaemic parameters, body weight and blood pressure, in adults with Type 2 Diabetes (T2D).1 Data from this pooled analysis are being presented at the 49th European Association for the Study of Diabetes (EASD) Annual Meeting.

“Management of Type 2 Diabetes in people with elevated cardiovascular risk represents a challenge for physicians” said John E. Gerich, M.D. Professor of Medicine and Physiology, University of Rochester School of Medicine. “Results from this pooled analysis showed that empagliflozin was associated with reductions of elevated blood pressure and modest body weight loss, in addition to improving glycaemic parameters. These are important considerations for people with Type 2 Diabetes.”

The pooled analysis of four Phase III trials was based on efficacy data from 2,477 patients treated with empagliflozin (10mg or 25mg) for 24 weeks either as monotherapy or as add-on to metformin, metformin with sulphonylurea, or pioglitazone with or without metformin. This abstract only presented pooled efficacy data; pooled safety results were presented in a separate analysis.2

At week 24, patients administered empagliflozin 10mg and 25mg showed:1

    Significant reductions from baseline in HbA1c of 0.70 percent and 0.76 percent respectively, compared to a change of -0.08 percent for placebo
    Loss of 2.05kg and 2.25kg of body weight respectively from baseline, compared to a reduction of 0.24kg for placebo
    Reductions in systolic blood pressure of 3.9mmHg and 4.3mmHg, and diastolic blood pressure of 1.8mmHg and 2.0mmHg, respectively. Reductions of 0.5mmHg in systolic blood pressure and 0.6mmHg in diastolic blood pressure were achieved by patients treated with placebo
    Changes from baseline in LDL cholesterol of +3.1mg/dL and +3.9mg/dL respectively, versus a change of +0.8mg/dL for placebo
    Changes from baseline in HDL cholesterol of +2.7mg/dL for both doses, versus a change of 0mg/dL for placebo
    Changes from baseline in triglyceride levels of -9.7mg/dL and -1.8mg/dL respectively, versus a change of +2.7mg/dL for placebo

“The results presented today encourage us to further investigate the efficacy and cardiovascular safety of empagliflozin as a potential new treatment option for people with Type 2 Diabetes,” said Professor Klaus Dugi, Senior Vice President Medicine, Boehringer Ingelheim.

In addition to the pooled analysis of efficacy data, Boehringer Ingelheim and Lilly are also presenting the design of the empagliflozin cardiovascular (CV) outcomes trial at the EASD annual meeting.

The long-term impact of treatment with empagliflozin on CV events is being investigated in a CV outcomes event trial in patients with T2D. The approximately four-year study of more than 7,000 patients with T2D at elevated CV risk, is investigating the long term treatment of empagliflozin versus placebo on CV morbidity and mortality in 42 countries at more than 620 sites.3

The primary endpoint is time to first occurrence of CV death, non-fatal myocardial infarction (heart attack) or non-fatal stroke. In addition, the study is assessing long term blood glucose lowering efficacy, body weight changes, the incidence of hypoglycaemia and other safety measures. Recruitment for EMPA-REG OUTCOME™ completed in April 2013 and the study is currently expected to complete in 2018.

About the empagliflozin Phase III clinical trial programme

Empagliflozin is being investigated in adults with T2D in a Phase III clinical trial programme, which has enrolled more than 14,500 patients. This programme comprises more than 10 multinational clinical trials.

* Empagliflozin is an investigational compound. Its safety and efficacy have not been established.

Please click on the link below for “Notes to Editors” and “References” http://www.boehringer-ingelheim.com/news/news_releases/press_releases/2013/24_september_2013empagliflozin.html

Contacts

Boehringer Ingelheim GmbH

Marco Winkler

Product Communication Manager

Email: press@boehringer-ingelheim.com

Phone: +49 (151) 689 46812



Lilly Diabetes

Tammy Hull

Communications Manager

Email: hullta@lilly.com

Phone: +1 (317) 651 9116







Permalink: http://www.me-newswire.net/news/8601/en

Rimini Street Appoints Jack L. Acosta to Board of Directors

ME NewsWire / BusinessWire

Software Industry Veteran and Former CFO of Sybase and Portal Software Appointed Independent Director and Chairman of Audit Committee for Leading Enterprise Software Support Company

SAN FRANCISCO - Tuesday, September 24th 2013

Oracle OpenWorld 2013

Oracle OpenWorld 2013 – Rimini Street, Inc., the leading third-party maintenance and support provider for enterprise software, including SAP AG’s (NYSE:SAP) Business Suite and BusinessObjects software and Oracle Corporation’s (NYSE:ORCL) Siebel, PeopleSoft, JD Edwards, E-Business Suite, Oracle Database, Hyperion and Oracle Retail software, today announced that Jack L. Acosta has been appointed to its Board of Directors as an Independent Director and Chairman of the Audit Committee.

Acosta, 65, is a veteran of the enterprise software industry with decades of board and operating experience. He currently serves on several technology company boards, with his most recent operational role serving as chief financial officer at Portal Software, Inc. (now part of Oracle). Prior to that, he served as executive vice president and chief financial officer for Sybase, Inc. (now part of SAP).

Prior to these roles, Acosta served as vice president, engineering services, integration and business management for Sybase. He also served as president, COO, and a director of Tanon Manufacturing, Inc. Earlier, Acosta held various management positions at Ungermann-Bass, Inc., Atari, Inc., Diablo Systems, Inc., and Ford Motor Company. Acosta holds a Bachelors of Science degree in Industrial Relations and a Masters of Science in Management Sciences. He also received an Honorary Doctor of Humane Letters degree from California State University East Bay (formerly Hayward).

“I have spent a majority of my career with successful companies who had the vision and capability of changing the global technology landscape through disruptive innovation, and I am excited to join Rimini Street’s board and work with this passionate, client-focused team to help further accelerate Rimini Street’s global expansion,” said Acosta. “Rimini Street is a well-run, high-growth organization with years of clean audited financial statements, and is redefining the enterprise software support space with its award-winning service offering that is already being enthusiastically embraced by nearly 700 clients around the world.”

“We are pleased to have someone with Jack’s extensive background and industry successes join Rimini Street’s Board of Directors and look forward to his contributions as we continue to accelerate global growth in accordance with our business plan,” said Seth Ravin, Rimini Street CEO. “Jack’s appointment to the important role of Chairman of the Audit Committee is a continuation of Rimini Street’s commitment to transparent and disciplined financial management and oversight that includes a rigorous focus on internal financial processes, systems and audits.”

About Rimini Street, Inc.

Rimini Street is the leading third-party provider of enterprise software support services. The company is redefining enterprise support services with an innovative, award-winning program that enables Oracle and SAP licensees to save up to 90 percent on total support costs over a decade, including saving 50 percent on annual support fees. Clients can remain on their current software release without any required upgrades or migrations for at least 10 years. Hundreds of global, Fortune 500, midmarket, and public sector organizations from virtually all industries have selected Rimini Street as their trusted, independent support provider. To learn more, please visit www.riministreet.com or call within the USA 888-870-9692 or internationally +1 702-839-9671.

Rimini Street and the Rimini Street logo are trademarks of Rimini Street, Inc. All other company and product names may be trademarks of their respective owners. Copyright © 2013. All rights reserved.

Contacts

Rimini Street, Inc.

Alma Park, +1 323-229-7282

apark@riministreet.com









Permalink: http://www.me-newswire.net/news/8594/en

Gemalto, Oracle and V2COM Collaborate to Deliver M2M Technology for Smart Grid Solutions in Latin America

ME NewsWire / Business Wire

AMSTERDAM - Tuesday, September 24th 2013

Regulatory News:

Gemalto (Euronext NL0000400653 GTO), the world leader in digital security, announces that it is working with Oracle and V2COM, a leading developer of Smart Grid systems, in delivering a flexible smart energy solution. This advanced Smart Grid Platform leveraging Gemalto’s Cinterion modules with Oracle Java ME Embedded and Oracle Java SE Embedded, will help to modernize electrical power delivery throughout Latin America. The unique combination of data security and modular, Java-based solutions will help enable leading-edge smart metering, along with “big data” integration and power network automation, to improve overall energy efficiency, as well as quality of service for utility companies.

V2COM’s innovative solution uses Gemalto’s Cinterion modules with Oracle Java ME Embedded to securely and reliably communicate energy usage data over wireless networks. These modules seamlessly communicate with V2COM’s Intellligenceware Suite, which uses Oracle Java SE Embedded, Oracle Utilities Meter Data Management (MDM) and GlassFish Server Open Source Edition to connect meter and sensor data into back-end utility IT systems. This allows electric companies to reduce energy losses and fraudulent incidents by improving remote monitoring and management of energy consumption. Quality of service to customers is also improved with faster response times when outages or other issues occur. The intelligent design is scalable, flexible and robust, and can be quickly customized to the individual demands of local market energy providers.

“Gemalto’s M2M solutions integrate seamlessly with V2COM and Oracle’s technologies. Together, we provide a simple, scalable and cost-effective smart energy architecture,” said Nandini Ramani, vice president of development, Java Platform, Oracle. “Supported by the world’s largest community of developers and deployed in over three billion devices worldwide, Java enables smart energy companies to rapidly create and adapt sophisticated M2M solutions that improve business. V2COM also works very closely with our dedicated Utilities Business Unit, implementing the leading Oracle Utilities Meter Data Management solution, which is key to the successful rollout of smart meters. It offers scalable, robust functionality, together with a full suite of analytics, to support utilities in Brazil and across the world.”

“We relied on Gemalto’s market-proven security expertise to design a solution that is unique in the market for safeguarding the integrity of the power grid infrastructure,” said Guilherme Spina, Managing Director, V2COM. “This solution is already deployed in various countries across Latin America, including Brazil which currently has 69 million installed energy meters and adds six to seven million new meters every year. In Colombia, for example, automated network management reduced response times to issues like power outages by 40 percent.”

“The modernization of the Brazilian electricity network requires a $23 billion investment by 2030 for various operational and technical improvements including smart meters, billing automation and quality control,” added Ramzi Abdine, Regional Manager for M2M at Gemalto Latin America. “Gemalto’s extensive expertise in smart metering and remote monitoring, and its customizable, reliable Java-based technology enable our customers to offer the most comprehensive solutions to utility companies that are upgrading their systems.”

Oracle and Java are registered trademarks of Oracle and/or its affiliates.

About Gemalto

Gemalto (Euronext NL0000400653 GTO) is the world leader in digital security with 2012 annual revenues of €2.2 billion and more than 10,000 employees operating out of 83 offices and 13 Research & Development centers, located in 43 countries.

We are at the heart of the rapidly evolving digital society. Billions of people worldwide increasingly want the freedom to communicate, travel, shop, bank, entertain and work – anytime, everywhere – in ways that are enjoyable and safe. Gemalto delivers on their expanding needs for personal mobile services, payment security, authenticated cloud access, identity and privacy protection, eHealthcare and eGovernment efficiency, convenient ticketing and dependable machine-to-machine (M2M) applications. We develop secure embedded software and secure products which we design and personalize. Our platforms and services manage these products, the confidential data they contain and the trusted end-user services made possible.

Our innovations enable our clients to offer trusted and convenient digital services to billions of individuals. Gemalto thrives with the growing number of people using its solutions to interact with the digital and wireless world.

For more information visit www.gemalto.com, www.justaskgemalto.com, blog.gemalto.com, or follow @gemalto on Twitter.

Contacts

Gemalto Media Contacts:

Europe, Middle East & Africa

Peggy Edoire, +33 4 42 36 45 40

peggy.edoire@gemalto.com



Asia Pacific

Pierre Lelievre, +65 6317 3802

pierre.lelievre@gemalto.com



North America

Nicole Smith, +1-512-758-8921

nicole.smith@gemalto.com



Latin America

Ernesto Haikewitsch, +55 11 5105 9220

ernesto.haikewitsch@gemalto.com



Permalink: http://www.me-newswire.net/news/8598/en

Tuesday, September 24, 2013

Robert Weinberg, Leroy Hood, Bob Löwenberg, Olli Kallioniemi, Rene Bernards, Guido Kroemer, Hans Clevers, Matthias Uhlen and Other Top Experts in Tumor Biology and Precision Cancer Medicine to Present at WIN 2014 Symposium

PARIS - Tuesday, September 24th 2013 [ME NewsWire]

Paris, June 23-24, 2014

WIN2014

(BUSINESS WIRE) WIN Consortium (www.winconsortium.org) announces today the scientific program of the upcoming WIN 2014 Symposium in Paris, June 23-24. The world’s leaders in tumor biology and precision cancer medicine will present keynote lectures in an exceptional event entirely dedicated to combination therapies for cancer under the title:

WINning combinations for precision cancer medicine: Breakthrough molecular investigations and combined therapeutic approaches

"This original theme is, for the first time, the subject of an international symposium," said Dr. Vladimir Lazar, Chief Operating Officer of the WIN Consortium.

"Most patients’ tumors are driven by multiple molecular aberrations that cannot be controlled by a single targeted agent. The challenge is to identify and test smart combinations of targeted agents capable of blocking pathways most effectively, or by combining different therapeutic modalities such as targeted and immunomodulatory agents or radiation therapy," said John Mendelsohn, Chair of the WIN Consortium.

Alexander Eggermont, Vice-Chair of WIN Consortium and co-chair of the WIN2014 Symposium together with Mike Pellini (USA) and Gerald Batist (Canada) stated: "We are very pleased to announce the participation of some of the undisputed thought-leaders in the field: Robert Weinberg (USA), Leroy Hood (USA), Hans Clevers (Netherlands), Olli Kallioniemi (Finland), Rene Bernards (Netherlands), Guido Kroemer (France) and many other colleagues that accepted our invitation to create an unprecedented scientific event dedicated to innovation in therapies to improve cancer patients’ outcomes and quality of life."

The scientific program will address major developments in precision cancer medicine in sessions featuring the world’s leaders in basic and clinical cancer research, each session focusing on the rationale for combinations. Sessions themes and confirmed speakers are:

    Molecular analysis of immune cells and immunotherapy: Jérôme Galon (France); George Coukos (Switzerland); Axel Hoos, GlaxoSmithKline, (USA); Guido Kroemer, (France)
    What can we learn from hemato-oncology? Bob Löwenberg, (Netherlands); Eric Solary (France); Ross Levin (USA); Jesus Gomez-Navarro, Millennium-Takeda (USA); Olli Kallioniemi (Finland)
    Innovative therapeutic initiatives and models of cooperation: Denis Lacombe (Brussels); Jean-Charles Soria (France)
    Tumor cell plasticity and drugable targets: Robert Weinberg (USA)
    Combination of targeted therapies: Hans Clevers (Netherlands); René Bernards, (Netherlands); Razelle Kurzrock (USA); Richard Buller, Pfizer (USA); Antoine Yver, AstraZeneca (UK); Silvia Formenti (USA); Elias Zerhouni, Sanofi (France)
    New findings in fundamental mechanisms in pediatric solid and liquid cancers: Stefan Pfister (Germany); Gilles Vassal (France)
    Blood and body fluids – non-invasive investigations in oncology: Leroy Hood (USA); Mathias Uhlen (Sweden); Caroline Dive (UK)

For program updates, registration, and call for abstracts, visit the WIN 2014 Symposium website: www.winsymposium.org

WIN2014 is the 6th edition of a successful series of conferences organized by the Worldwide Innovative Networking (WIN) Consortium in personalized cancer medicine (www.winconsortium.org).

The WIN Consortium is a not-for-profit global collaboration of leading academic, industry, health plan, and advocacy organizations that runs global research projects identifying biomarkers for targeted therapies and clinical trials investigating targeted cancer treatments. WIN’s mission is to accelerate the pace and reduce the cost of translating the most promising innovations in personalized cancer medicine into the standard of care worldwide.

Contacts

For further information about the WIN2014 Symposium contact:

WIN 2014 Symposium Secretariat

Congress by design

win@congressbydesign.com

Tel. +31 88 089 8101



For further information about the WIN Consortium contact:

Catherine Bresson

Director, Operational Team

Catherine.Bresson@winconsortium.org







Permalink: http://www.me-newswire.net/news/8600/en