Amazfit Expands Active 2 Lineup with the New Active 2 Square — All the Same Features, Now in a Sleek Square Design

 MILPITAS, Calif. - Tuesday, 17. June 2025 AETOSWire Print 

(BUSINESS WIRE)--Amazfit, a leading global smart wearable brand owned by Zepp Health (NYSE: ZEPP), a health technology company, today announced the launch of the square version of the Amazfit Active 2, a new addition to its fitness smartwatch line that offers the same powerful features and premium experience as the recently launched round Active 2 — now in a modern, square form factor.

Same Features. New Shape.

Debuting at CES 2025 and featured at Pepcom and ShowStoppers, the Active 2 Square is designed for consumers who prefer a bold, geometric aesthetic without compromising performance, durability, or advanced health and fitness tracking.

Featuring a square, 1.75 inch sapphire glass high-definition AMOLED display elegantly encased in a polished stainless-steel frame, the Amazfit Active 2 delivers an optimal visual experience with a peak brightness of 2,000 nits, ensuring clarity even in bright light.

The graceful metal finish adds a sophisticated touch, perfectly complementing modern, style-conscious lifestyles. Its distinctive geometric form reflects a unique design identity and its intuitive interface and expansive viewing surface provide seamless access to health metrics, messages, and workouts. The device retains the full suite of features that made the round Active 2 a standout.

Product Specs

Latest Generation Biosensor: The BioTracker™ 6.0 PPG biosensor features a dual-LED and 5PD build, which picks up more biometric signals for enhanced precision in health monitoring and measurement.

Upgraded Heart Rate and Sleep Algorithms: The PulsePrecision™ algorithm enhances heart rate tracking accuracy to the level of the Amazfit T-Rex 3, while the RestoreIQ™ algorithm gives sleep monitoring a similar accuracy boost.

Additional Sensors: Compared to the previous generation of Amazfit Active, the new release adds a barometer for accurate altitude measurements and support of new sports like skiing, along with an accelerometer and gyroscope for precise recognition of sleep and movement, and an ambient light sensor for optimal display under varying light conditions.

Extended Battery Life: With a robust 10-day battery life under typical use, the Active 2 Square is a device that won't need recharging every night.

Zepp Flow™: Enables users to control their watch settings, adjust their calendar, and more with just their voice, while also granting Android users the ability to reply to instant messages with either keyboard or speech-to-text input.

Fitness and Wellness Features

Dynamic Fitness Modes: Over 160 sports modes including official HYROX Race Mode, a smart Strength Training mode that can auto-detect specific exercises and intelligently count reps, sets, and rest time, and new winter sports like Skiing.

Offline Maps with Turn Directions: Supported by 5 satellite systems, users can navigate with ease by importing offline maps and route files to the watch that come with turn-by-turn directions, which can be followed on-screen or broadcast via the built-in speaker or the user's connected Bluetooth headphones.

Zepp Coach™ Integration: Offers personalized training and running plans, empowering users of all levels to achieve fitness milestones from 3K runs to full marathons.

Tailored for Women: With the Wild.AI mini app, women can connect to their accounts directly from the watch for personalized wellness insights tied to their menstrual and hormonal cycles.

Advanced Health Insights: A daily Readiness score summarizes mental and physical recovery and provides actionable insights, while the HRV feature delivers specialized recovery data.

Availability and Pricing

The Amazfit Active 2 Square is available for purchase beginning today on Amazfit.com and Amazon. Priced at $149.99 USD or €149.90 euro, the Active 2 Square delivers premium features and performance at an unbeatable value.

For more information, please visit https://www.amazfit.com/en/ and follow us on Facebook, Instagram, X (formerly Twitter) and YouTube.

About Amazfit

Amazfit, a leading global smart wearable brand focused on health and fitness, is part of Zepp Health (NYSE: ZEPP), a health technology company with its principal office based in Gorinchem, the Netherlands. Zepp Health operates as a distributed organization, with team members and offices across the Americas, Europe, Asia, and other global markets.

Offering a wide selection of smartwatches and bands, Amazfit's brand tagline, “Discover Amazing,” encourages individuals to break barriers, exceed expectations, and find joy in every moment. Amazfit is powered by Zepp Health’s proprietary health management platform, which delivers cloud-based, 24/7 actionable insights and guidance to help users achieve their wellness goals.

Known for outstanding craftsmanship, Amazfit smartwatches have won numerous design awards, including the iF Design Award and the Red Dot Design Award. Launched in 2015, Amazfit is embraced by millions of users, with products available in over 90 countries across the Americas, EMEA, and APAC regions. For more information, visit www.amazfit.com.

 

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Media Contact

Mary Thompson Woodbury

Head of PR, North America

mary.woodbury@zepp.com

EDB Postgres® AI Accelerates New Era of Sovereign Data and AI for Enterprises, Industries, and Nations

 The first secure Postgres platform that unifies transactional, analytical, and AI—democratizing agentic AI across hybrid environments through an easy-to-use interface

EDB introduces new capabilities to the industry’s first Postgres-based data and AI platform, allowing enterprises to easily manage, observe, and democratize the use of agentic AI within a sovereign setting.

Only 13% of enterprises globally have successfully deployed a broad set of agentic AI applications at scale, according to EDB research (May 2025). These early leaders are seeing dramatically better returns—up to 227% higher ROI than the remaining 87%, and 23% better ROI than the next-best group—so this launch is essential for businesses who want to come out on top in the AI race.

EDB Postgres AI transforms core operational data into an AI-ready asset, with just five lines of code to set up an AI pipeline that automatically syncs embeddings with source data, taking AI from concept to production 3x faster while cutting costs by 50%.

 

(BUSINESS WIRE) -- EnterpriseDB (EDB), the leading Postgres data and AI company, today announced new innovations to the EDB Postgres AI (EDB PG AI) platform designed to help enterprises deploy and scale AI securely and compliantly across their Postgres environments, whether in clouds or on-premises. The platform streamlines operations at scale, integrates easily with existing data ecosystems, and centralizes hybrid management and observability in a single AI-ready control plane for the emerging era of agentic AI. See the demonstrations and configure your sovereign AI and platform at www.enterprisedb.com.

EDB PG AI is a unified platform with an easy-to-use interface for managing transactional, analytical, and AI workloads. As the industry’s first Postgres-based sovereign data and AI platform, it unifies relational and non-relational data in a single system, featuring automatic pipelines and built-in development tools that seamlessly automate and operationalize data for AI.

“In this AI-first, sovereign-first world, C-suite executives in every geo point to a single, urgent need: a secure, open source, sovereign data and AI platform that gives them full control over how and where they build their AI future. True data and AI sovereignty means we are giving enterprises the freedom to choose—hybrid, with unique engineered systems, software, and cloud offerings—while also ensuring that they have the security and control they need,” said Kevin Dallas, CEO, EDB.

Only 13% of enterprises globally have successfully deployed a broad set of agentic AI applications at scale, according to EDB research (May 2025). These early leaders are seeing dramatically better returns—up to 227% higher ROI than the remaining 87% and 23% better ROI than the next-best group.

“Globally, customers are increasingly turning to tested, optimized, and scalable architecture to more effectively implement open source AI at the enterprise level. To help meet this need, Red Hat collaborates through a robust partner ecosystem, including EDB, to help empower organizations with the solutions, services, and support they need to drive successful business outcomes with AI. Using EDB Postgres AI with Red Hat OpenShift AI, organizations can benefit from a more consistent platform for sovereign control of a company’s data and its own AI models,” said Stefanie Chiras, senior vice president, Partner Ecosystem Success, Red Hat.

The EDB PG AI platform introduces two new core capabilities that enable secure, scalable, and hybrid-ready agentic AI, bringing production-grade performance mainstream for enterprises across their Postgres estates:

Low-code/no-code simplicity: AI pipeline creation in days, not months

Developers and business users can easily build intelligent applications using a simple point-and-click interface and low-code software development kit (SDK)—transforming GenAI projects from concept to production in days instead of months within a pre-integrated platform. In just five lines of code, users can set up an AI pipeline that automatically syncs embeddings with source data, ensuring an always-up-to-date AI knowledge base without costly infrastructure maintenance.

NVIDIA accelerated computing delivers the processing performance required for this new compute paradigm, while NVIDIA NIM microservices enable enterprises to run AI models locally and protect their data with sovereign AI. EDB Postgres AI integrates NVIDIA NeMo Retriever extraction, embedding and re-ranking microservices to ingest and process multimodal enterprise data, along with a catalog of NIM microservices to facilitate AI model extension.

Together, these capabilities help enterprises operationalize their AI—securely, at scale, and on their infrastructure of choice.

Sovereign hybrid Postgres data estate management and observability

Hybrid management delivers comprehensive visibility across the entire Postgres estate, empowering developers and operators with real-time insights across hundreds of databases through an intuitive interface. With 200+ built-in metrics and intelligent recommendations, teams can identify and resolve issues 5x faster, boost application performance by up to 8x, and optimize infrastructure—no DBA expertise required. Anyone can optimize performance and manage large estates with ease, boosting productivity by up to 30% while cutting TCO up to 6x compared to legacy systems.

“The EDB Postgres AI engineered solution leverages several of Supermicro’s strengths, including our portfolio of data center building block systems, experience in developing and delivering rack-scale AI solutions, and our experience in supporting OEM customers like EnterpriseDB,” said Cenly Chen, chief growth officer, senior vice president, and managing director, Supermicro B.V. “This unified solution offers full hybrid capabilities and helps customers build sovereign, scalable, and compliant data and AI systems, giving enterprises the control and near-instant access to data needed for Gen AI.”

Explore the comprehensive library of benchmarks here. Additional platform enhancements include:

Data security at all layers with Transparent Data Encryption (TDE), supply chain security, and hardened container images from Iron Bank. Advanced security features include role-based access control with fine-grained permissions down to row level, robust audit logging for real-time threat detection, and data redaction to limit sensitive information exposure—ensuring compliance with evolving regulations including PCI DSS and SOC 2.

Purpose-built PG AI Analytics Engine scales independently from storage and is optimized for columnar formats such as Iceberg and Delta tables, driving high performance queries across Postgres and the lakehouse ecosystem. Enterprises can unlock insights 30x faster than standard Postgres by using fresh operational data, breaking down silos, and eliminating ETL pipelines. Intelligent tiering offloads cold transactional data to storage that is up to 18x more cost efficient.

A universal, secure data store supports all types of data models—SQL, vector, JSON, time-series, key-value, and more—for building applications with structured, semi-structured, and unstructured data types. Tiered storage and a query engine unify Postgres with scalable analytics tables in object storage. EDB PG AI delivers optimized read/write performance that scales seamlessly from high-concurrency transactions to complex analytical and vector queries, all within a hybrid, sovereign architecture. Proven performance advantages include:

6x better TCO and 30% faster transactional performance than SQL Server

Up to 150x faster NoSQL performance vs. MongoDB

Up to 4x faster NoSQL performance vs. MySQL

“McKnight Consulting Group compared the integrated EDB Postgres AI platform against a usual DIY approach using AWS. Across all the eight critical components of an enterprise AI factory, EDB Postgres AI reduced overall complexity by 67%, delivered a 3x faster design-to-delivery capability (from seven months to nine weeks), and a 38% reduction in maintenance complexity and costs,” said William McKnight, president, McKnight Consulting Group.

EDB PG AI represents a turning point for enterprises seeking to harness the full power of their data in the agentic AI era. To witness how your enterprise can accelerate AI initiatives with confidence while maintaining complete control of data assets, configure your own sovereign and AI platform at www.enterprisedb.com.

About EDB

EDB Postgres® AI (EDB PG AI) is the first open, enterprise-grade sovereign data and AI platform—secure, compliant, and scalable, on-premises and across clouds. Built on Postgres, the world’s leading database, EDB PG AI unifies transactional, analytical, and AI workloads, enabling organizations to operationalize their data and LLMs while maintaining control over sovereign environments. EDB PG AI is supported by a global partner network and delivers up to 99.999% availability as well as hybrid management and a built-in AI factory. As one of the most active contributors to the PostgreSQL project, EDB is deeply invested in the vitality of the global community. To learn more, visit www.enterprisedb.com.

EnterpriseDB and EDB are registered trademarks of EnterpriseDB Corporation. Postgres and PostgreSQL are registered trademarks of the PostgreSQL Community Association of Canada and used with their permission. All other trademarks are owned by their respective owners.

 

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Media Contact:

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Marketbridge for EDB

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New CSC Survey Finds Overwhelming Majority of CISOs Anticipate Surge in Cyber Attacks Over the Next Three Years

WILMINGTON, Del. - Monday, 16. June 2025

CISOs identify cybersquatting, domain-based attacks, and ransomware as top cybersecurity concerns

87% cite AI-powered domain generated algorithms as a direct threat

Only 7% expressed clear confidence in their ability to combat domain attacks

 

(BUSINESS WIRE) -- An overwhelming 98% of chief information security officers (CISOs) expect a surge in cyber attacks over the next three years as organizations face an increasingly complex and artificial intelligence (AI)-driven digital threat landscape. This is according to new research conducted among 300 CISOs, chief information officers (CIOs), and senior IT professionals by CSC1, the leading provider of enterprise-class domain and domain name system (DNS) security.

The report, “CISO Outlook 2025: Navigating Evolving Domain-Based Threats in an Era of AI and Tightening Regulation,” names cybersquatting, domain and DNS hijacking, and distributed denial-of-service (DDoS) attacks as the top three global cyber threats in 2024. These risks are only projected to escalate, as cybercriminals leverage new techniques and capabilities from AI and other modern technologies to launch more sophisticated attacks. Looking ahead, cybersquatting, domain-based attacks, and ransomware top the list of cybersecurity concerns for CISOs over the next three years.

“DNS and domain-related infrastructure are prime targets for cybercriminals,” says Ihab Shraim, chief technology officer for CSC’s Digital Brand Services division. “These attackers conduct extensive reconnaissance to identify vulnerabilities, hijack subdomains, and impersonate brands at a massive scale. With the growing availability of AI-driven tools and off-the-shelf attack kits, these threats are only going to accelerate. A single DNS compromise can take down email, websites, customer portals, and even phone networks. Companies that don’t act quickly may find themselves navigating not just technical fallout, but reputation and regulatory consequences as well.”

AI-powered domain generation algorithms (DGAs) are increasingly worrisome, with 87% of CISOs identifying them as a direct threat. Additionally, 97% of respondents voiced concerns about the potential risks associated with granting third-party AI systems access to company data, underscoring the critical need for robust AI governance frameworks.

Despite these escalating concerns, only 7% of CISOs expressed being “very confident” in their ability to mitigate domain-based attacks, and just 22% believe they have the right tools in place. This lack of confidence may reflect deeper gaps in preparedness, and it’s possible that many organizations still underestimate the complexity of domain security and the speed at which threats are evolving.

“The human element continues to be the biggest security vulnerability,” adds Nina Hrichak, vice president of CSC’s Digital Brand Services. “As cybercriminals grow more sophisticated, internal education and awareness are falling behind. DNS hijacking and subdomain takeovers have become mainstream concerns, but not every organization possesses the internal expertise to monitor domain activity in real time. That’s where experienced partners can offer vital insights and agility to help organizations stay ahead of the curve.”

To receive a copy of CSC’s “CISO Outlook 2025: Navigating Evolving Domain-Based Threats in an Era of AI and Tightening Regulation,” contact us at CSC@w2comm.com or visit the website.

1CSC, in partnership with Pure Profile, surveyed 300 CISOs, CIOs, and senior IT professionals operating in Europe, the U.K., North America, and Asia Pacific to understand their current concerns and how they are navigating the evolving cybersecurity landscape, regulatory demands, and the rise of AI in cybercrime.

About CSC

CSC is the trusted security and threat intelligence provider of choice for the Forbes Global 2000 and the 100 Best Global Brands (Interbrand®) with focus areas in domain security and management, along with digital brand and fraud protection. As global companies make significant investments in their security posture, our DomainSec℠ platform can help them understand cybersecurity oversights that exist and help them secure their online digital assets and brands. By leveraging CSC’s proprietary technology, companies can solidify their security posture to protect against cyber threat vectors targeting their online assets and brand reputation, helping them avoid devastating revenue loss. CSC also provides online brand protection—the combination of online brand monitoring and enforcement activities—with a multidimensional view of various threats outside the firewall targeting specific domains. Fraud protection services that combat phishing in the early stages of attack round out our solutions.

Headquartered in Wilmington, Delaware, USA, since 1899, CSC has offices throughout the United States, Canada, Europe, and the Asia-Pacific region. CSC is a global company capable of doing business wherever our clients are—and we accomplish that by employing experts in every business we serve. Visit cscglobal.com.

 

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For more information:

W2 Communications

Joyson Cherian

Senior Vice President

Joyson@w2comm.com

CSC

Laura Crozier

PR Manager

laura.crozier@cscglobal.com

CSC News Room

Smoke Free Sweden: Oral Nicotine Pouches Are Game-changer for Women in Sweden's Smoke-free Success

  STRASBOURG, France - Tuesday, 17. June 2025 AETOSWire 

First-of-its-kind study reveals female-friendly pouches are transforming the fight against cigarettes

(BUSINESS WIRE) -- New research from Smoke Free Sweden reveals oral nicotine pouches are a game-changer in Sweden’s path to becoming the world’s first smoke-free nation – and are driving unprecedented success among women.

The report, Power in a Pouch, launched today in Strasbourg, shows pouches have been a decisive catalyst in Sweden’s public health success – especially for women, who are quitting smoking faster and more effectively than ever.

Since their introduction in 2016, tobacco-free pouches have:

Helped to accelerate the decline in smoking for both genders, with a nearly 200% rise in quit rates among women.

Outperformed all other quit aids; women ranked pouches nearly three times higher than vapes and 56% higher than gum.

Been identified by the research as the preferred quit aid for all ex-smokers for being clean, socially considerate and stigma-free.

Driven a 49% drop in smoking among women, who historically quit at lower rates than men.

“The evidence is crystal clear: nicotine pouches are the most effective way to help smokers – especially women – quit,” said report co-author Dr. Marewa Glover, a behavioural scientist from New Zealand.

“Health data and women’s testimonials show pouches are safe, socially acceptable, and fit modern lifestyles. They’re pragmatic, effective, and our best hope for a smoke-free future.”

Sweden’s harm reduction strategy stands in contrast to restrictive approaches elsewhere. Rather than banning safer products, Sweden embraced them – recognising they are far less harmful than cigarettes.

Sweden’s smoking rate is now 5.3%, just above the 5% smoke-free benchmark. Male lung cancer deaths are 61% below the EU average; total cancer deaths, 34% lower.

Report co-author Dr. Delon Human warned that excessive regulation could jeopardise these gains, especially for women.

“Misguided bans are blocking access to products that save lives,” said Dr. Human, leader of Smoke Free Sweden and former Secretary-General of the World Medical Association.

“That’s not just bad policy – it’s a public health disaster. Women deserve access to the quit aid that works best.”

Dr. Glover added: “When women can choose clean, stigma-free options, quit rates soar. Denying access means condemning another generation to smoking-related death.

“Policymakers must follow Sweden’s lead – or be complicit in preventable deaths on a massive scale.”

 

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CSG & AWS Expand Collaboration to Accelerate Cloud Transformation in Telecommunications & Financial Services

 New initiative reduces total cost of ownership by up to 60% and boosts cloud migration for global enterprises

(BUSINESS WIRE) -- In a rapidly evolving digital economy, telecommunications and financial services companies face mounting pressure to modernise, scale operations and unlock innovation—all while managing costs and navigating complex growth journeys. Today, CSG® (NASDAQ: CSGS) announced a new strategic collaboration agreement with Amazon Web Services (AWS) to fast-track cloud transformation across these industries. The initiative will come to life through advanced cloud-native technologies, cost optimisation and platform innovation.

“As industries double down on cloud transformation, they need scalable, cost-efficient platforms that can evolve with them,” said Mayoor Mahendra, Vice President, Network Solutions, CSG. “Our extended collaboration with AWS amplifies the value of CSG’s Converged Mediation solution by pairing it with AWS’s global infrastructure. Together, we’re helping telco and banking and financial services leaders modernise faster, reduce costs and innovate with confidence.”

Building on a long-standing collaboration, this initiative brings CSG’s enhanced mediation capabilities to the AWS Marketplace. The solution delivers up to 60% total cost of ownership savings and accelerates customers’ journey to the cloud while unlocking new operational efficiencies. CSG and AWS will co-invest to expand access to cloud-native capabilities through technical enablement, go-to-market collaboration and ongoing platform innovation. In turn, CSG customers gain access to advanced technologies like AI, Agentic AI and GenAI—empowering them to scale efficiently, monetise investments and deliver differentiated experiences that build trust and long-term loyalty.

“AWS, along with CSG, is committed to helping our CSP customers advance in their digital transformation journey,” said Michael Singer, Director of North America Telecommunications, AWS. “This collaboration underscores our shared vision to help global enterprises modernise with a cloud-native approach, improve business outcomes with GenAI and deliver enhanced customer experiences.”

CSG and AWS will jointly present the benefits of the enhanced collaboration at the upcoming TM Forum DTW Ignite 2025 in Copenhagen. Stop by the CSG booth (#310) to learn more.

About CSG

CSG empowers companies to build unforgettable experiences, making it easier for people and businesses to connect with, use and pay for the services they value most. Our customer experience, billing and payments solutions help companies of any size make money and make a difference. With our SaaS solutions, company leaders can take control of their future and tap into guidance along the way from our fiercely committed and forward-thinking CSGers around the world.

Want to be future-ready and a change-maker like the global brands that trust CSG? Visit csgi.com to learn more.

 

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CSG Contacts:

Kristine Østergaard

Public Relations

+44 (0)79 2047 7204

kristine.ostergaard@csgi.com

John Rea

Investor Relations

+1 (210) 687-4409

john.rea@csgi.com

Davis Barker

Investor Relations

+1 (303) 884-4506

davis.barker@csgi.com

 

Kinaxis Announces Results of Voting at Annual Meeting of Shareholders>

(BUSINESS WIRE)--Kinaxis® Inc. (“Kinaxis” or the “Company”) (TSX:KXS), a global leader in end-to-end supply chain orchestration, received approval for all resolutions put forward to shareholders at today’s Annual Meeting of Shareholders (the “Meeting”), as detailed in the Company’s management information circular dated April 28, 2025 (the “Circular”). 1. Election of Directors Shareholders voted to elect all seven directors nominated to the Kinaxis board, to hold office until the close of the next annual meeting of shareholders of the Company or until their successors are elected or appointed. Name of Nominee Total Number of Votes For Percentage of Votes For Total Number of Votes Against Percentage of Votes Against Robert Courteau 22,065,236 95.74% 982,599 4.26% Gillian (Jill) Denham 22,357,176 97.00% 690,659 3.00% José Alberto Duarte 22,430...(BUSINESS WIRE)--Kinaxis® Inc. (“Kinaxis” or the “Company”) (TSX:KXS), a global leader in end-to-end supply chain orchestration, received approval for all resolutions put forward to shareholders at today’s Annual Meeting of Shareholders (the “Meeting”), as detailed in the Company’s management information circular dated April 28, 2025 (the “Circular”). 1. Election of Directors Shareholders voted to elect all seven directors nominated to the Kinaxis board, to hold office until the close of the next annual meeting of shareholders of the Company or until their successors are elected or appointed. Name of Nominee Total Number of Votes For Percentage of Votes For Total Number of Votes Against Percentage of Votes Against Robert Courteau 22,065,236 95.74% 982,599 4.26% Gillian (Jill) Denham 22,357,176 97.00% 690,659 3.00% José Alberto Duarte 22,430...{}

Ferrer Receives FDA Fast Track Designation for FNP-223 in Progressive Supranuclear Palsy (PSP)

 (BUSINESS WIRE) -- Ferrer, a B Corp-certified international pharmaceutical company, has announced that FNP-223, a novel therapy in-licensed from Asceneuron and aimed at slowing the development of progressive supranuclear palsy (PSP), has received Fast Track designation from the US Food & Drug Administration (FDA). FNP-223, a new molecular entity in active development for PSP, is in an ongoing Phase 2 study to evaluate its safety, efficacy, and pharmacokinetics in adult patients with possible or probable PSP-Richardson syndrome (PSP-RS), the most common clinical variant of this neurodegenerative disease1.

“We are thrilled to receive Fast Track designation from the FDA for FNP-223 in the treatment of PSP. Consistent with our purpose of using business to fight for social justice, we are committed to advancing this promising therapy as quickly as possible to benefit as many patients as possible,” said Mario Rovirosa, Chief Executive Officer of Ferrer.

Fast Track designation is a significant milestone in the drug development process. It is a program that offers the possibility of having more frequent meetings with the FDA to discuss the drug’s development, eligibility for Accelerated Approval and Priority Review if relevant criteria are met.

“This designation underscores the importance of expediting the development and review of FNP-223 to address critical unmet needs in patients with this rare and devastating disease,” said Marta Parmar, Ferrer’s Chief Quality, Regulatory and Pharmacovigilance Officer.

Progressive supranuclear palsy manifests in patients with symptoms such as difficulty speaking, imbalance, changes in gait, cognitive problems2-4. PSP has a prevalence of approximately 5 cases per 100,000 people and primarily affects individuals over the age of 603. The disease's etiology is believed to be related to the abnormal accumulation of tau proteins in certain areas of the brain, leading to neurodegeneration3,4. Preclinical models have demonstrated that FNP-223 can prevent the abnormal accumulation of tau proteins in neurons5. Ferrer now aims to show that this molecule is safe and effective in patients with PSP.

Oscar Pérez, Chief Scientific Officer of Ferrer, also expressed his enthusiasm: "Receiving Fast Track designation is a significant milestone in our journey to provide a transformative treatment for PSP. We are excited to advance our research and hopefully offer a new therapeutic option earlier for patients living with this challenging condition."

About FNP-223

FNP-223 is a new orally administered chemical compound that functions as a reversible and substrate-competitive inhibitor of the O-GlcNAcase (OGA) enzyme5. Mechanistically, FNP-223 binds to the active site of OGA enzyme. As a result, the inhibitor prevents the substrate from accessing the catalytic pocket, thereby impeding the removal of O-GlcNAc modifications from natural client proteins such as the tau protein. Inhibiting O-GlcNAcase is expected to cause a rapid increase of O-GlcNAcylated (glycosylated) tau proteins, ultimately leading to a reduction in abnormal aggregated tau as neurofibrillary tangles (NFT) over a certain period5.

Bibliography:

1. ClinicalTrials.gov A Randomized, Double-blind, Placebo-controlled, Phase 2 Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 (Oral Formulation) to Slow the Disease Progression of Progressive Supranuclear Palsy (PSP) (PROSPER). ClinicalTrials.gov [Internet]. Available from: https://www.clinicaltrials.gov/study/NCT06355531.

2. Coughlin DG, Litvan I. Progressive supranuclear palsy: Advances in diagnosis and management. Parkinsonism Relat Disord. 2020 Apr;73:105-116. doi: 10.1016/j.parkreldis.2020.04.014. Epub 2020 May 25.

3. Agarwal S, Gilbert R. Progressive Supranuclear Palsy. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526098/.

4. Rowe JB, Holland N, Rittman T. Progressive supranuclear palsy: diagnosis and management. Pract Neurol. 2021;21(5):376-383. doi: 10.1136/practneurol-2020-002794.

5. Permanne B, Sand A, Ousson S, Nény M, Hantson J, Schubert R, et al. D. O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies. ACS Chem Neurosci. 2022 Apr 20;13(8):1296-1314. doi: 10.1021/acschemneuro.2c00057.

 

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gortizdez@ferrer.com

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